Effect of dimenhydrinate on neural tube development in early chick embryo model
نویسندگان
چکیده
Amaç: Bu çalışmada dimenhidrinat’ın erken dönem civciv embriyo modelinde nöral tüp gelişimi üzerindeki etkilerinin araştırılması amaçlanmıştır.
 Gereç ve Yöntem: Çalışmada 32 fertil, spesifik patojen olmayan yumurta kullanıldı. Tüm yumurtalar her bir grupta 8 adet olacak şekilde dört gruba ayrıldı. İnkübasyonun 28. saatinde deney gruplarına üç farklı dozda (0,7, 1,4, 2,1 mg/kg) dimenhidrinat kontrol grubuna serum fizyolojik enjekte edildi. 48. tüm embriyolar diseke edildi ışık mikroskobu altında histolojik olarak değerlendirildi.
 Bulgular: Kontrol, düşük, orta yüksek doz grubu embriyoları morfolojik değerlendirildiğinde, kraniokaudal uzunluk ortalamaları sırasıyla; 8493,73±1342,90 µm, 5743,61±770,3 5572,62±315,32 5306,55±1135,99 somit sayıları 15,91±1,62, 15,38±1,19, 15,13±0,83, 10,63±5,15‘dir. Dimenhidrinat dozundaki artışa bağlı uzunluklarının sayılarının azaldığı tespit artışına açıklığının arttığı belirlendi .
 Sonuç: çalışmada, uygulanan gruplarda nörogenezisin gelişimin olumsuz etkilendiği görüldü.
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ژورنال
عنوان ژورنال: Cukurova Medical Journal
سال: 2022
ISSN: ['2602-3040', '2602-3032']
DOI: https://doi.org/10.17826/cumj.1092601